Prepare with ACRP ACRP-CP exam practice material, pass for sure

Updated: Aug 12, 2026

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ACRP ACRP-CP Exam Overview:

Certification Vendor:Association of Clinical Research Professionals (ACRP)
Exam Name:ACRP Certified Professional Exam
Exam Number:ACRP-CP
Available Languages:English
Passing Score:Scaled score of 600 or higher
Exam Price:$435 – $600
Exam Duration:180 minutes
Related Certifications:ACRP Certified Clinical Research Associate (CCRA)
ACRP Certified Clinical Research Coordinator (CCRC)
ACRP Certified Principal Investigator (CPI)
Certificate Validity Period:3 years
Exam Format:Multiple-choice questions, Recall questions, Scenario-based questions
Real Exam Qty:125 (100 scored, 25 pre-test)
Recommended Training:ACRP Official Training Resources
Exam Registration:ACRP Official Registration
Sample Questions:ACRP ACRP-CP Sample Questions
Exam Way:Online remote proctored or in-person at PSI test centers
Pre Condition:3,000 hours verifiable clinical research work experience; or 1,500 hours plus clinical research degree
Official Syllabus URL:https://acrpnet.org/certification/acrp-cp-certification

ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Data Management and Informatics17%- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E11 Pediatric Trials
  • 2. E8 General Considerations for Clinical Trials
  • 3. E2A Expedited Reporting
  • 4. E9 Statistical Principles
  • 5. E6(R2)/E6(R3) Good Clinical Practice
Clinical Study Operations15%- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
Study Design and Conduct17%- Study planning
  • 1. Protocol development and amendments
  • 2. Study population and eligibility criteria
  • 3. Sample size and statistical considerations
- Study implementation
  • 1. Investigational product management
  • 2. Study monitoring and oversight
  • 3. Site selection and activation
Ethical and Participant Safety Considerations19%- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Informed consent development and review
  • 3. Continuity of medical care
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy

ACRP Certified Professional Sample Questions:

1. A study sponsor approaches a facility about participating in their research study. The study sponsor requires use of social media as its sole method of recruitment. The site knows their institutional IRB/IEC does not approve of social media recruiting. How should the site respond?

A) Recruit for the study without use of social media.
B) Rely on the sponsor to notify the IRB/IEC.
C) Decline the study.
D) Use a central IRB/IEC.


2. A protocol requires participants to take IP for 6 months. The protocol allows for any participants who are noncompliant to be replaced by enrolling additional participants, except if it is due to an AE. The investigator has enrolled 12 participants.
The status of the enrolled participants is as follows:
* 3 participants were withdrawn due to noncompliance
* 1 participant withdrew consent after experiencing severe nausea
* 1 participant had to discontinue IP for an unscheduled hospitalization
* 1 participant who is not returning for visits
* 2 participants completed the 6 months of treatment
* 4 participants currently on IP
How many participants should be replaced?

A) 4 participants
B) 6 participants
C) 3 participants
D) 5 participants


3. During a monitoring visit, a CRA notices that a piece of equipment required for the study needs to be serviced. Who is responsible for addressing this problem?

A) CRC
B) CRA
C) Sponsor
D) PI


4. At a close-out visit, which document should be retained only at the site?

A) Subject identification code list
B) Treatment allocation
C) IP accountability
D) Final trial close-out monitoring report


5. Preliminary evidence suggests a low-dose anti-cancer drug given for a short period of time may reduce the risk of developing cancer in patients who are at increased risk for developing cancer. The drug has potentially serious side effects. What is the MOST important question to consider before designing a clinical trial to test this hypothesis?

A) How willing are current patients to participate in a trial with potentially serious side effects?
B) How likely are patients at high risk of cancer going to develop cancer during the study?
C) How effective is the drug at treating patients that have been previously diagnosed with cancer?
D) How does the risk of developing cancer compare to the anticipated side effects from the drug?


Solutions:

Question # 1
Answer: C
Question # 2
Answer: C
Question # 3
Answer: D
Question # 4
Answer: A
Question # 5
Answer: D

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