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Last Updated: Sep 29, 2026

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Data Management and Informatics17%- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E2A Expedited Reporting
  • 2. E6(R2)/E6(R3) Good Clinical Practice
  • 3. E8 General Considerations for Clinical Trials
  • 4. E11 Pediatric Trials
  • 5. E9 Statistical Principles
Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Human subject protections and privacy
  • 2. Clinical equipoise and therapeutic misconception
- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Clinical care and management of research participants
  • 1. Informed consent development and review
  • 2. Continuity of medical care
  • 3. Standard of care vs protocol requirements
Clinical Study Operations15%- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
Study Design and Conduct17%- Study planning
  • 1. Study population and eligibility criteria
  • 2. Sample size and statistical considerations
  • 3. Protocol development and amendments
- Study implementation
  • 1. Investigational product management
  • 2. Site selection and activation
  • 3. Study monitoring and oversight

ACRP Certified Professional Sample Questions:

Question #1

The investigator/institution should permit:

  • A. Monitoring and auditing by the appropriate regulatory authority(ies), and inspection by the sponsor.
  • B. Monitoring and auditing by the sponsor, and inspection by the appropriate regulatory authority(ies).
  • C. Monitoring and inspection by the sponsor, and auditing by the appropriate regulatory authority(ies).
  • D. Monitoring and inspection by the appropriate regulatory authority(ies), and auditing by the sponsor.
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Correct Answer: D  🗳️

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Question #2

Which of the following is a conflict of interest for a PI conducting a study?

  • A. A PI that votes on the IRB/IEC approval of the protocol
  • B. A PI who receives payment for the study
  • C. A PI who is a key opinion leader, writes the protocol
  • D. A PI that presents at an investigator meeting
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Correct Answer: A  🗳️

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Question #3

A representative from a regulatory authority shows up unannounced at a research site. After confirming their credentials, the representative requested to view the entire records, including identifiable information, from study XYZ that was closed out. Which of the following should the site personnel do next?

  • A. Redact subject identification for privacy protection.
  • B. Allow access to the entire records.
  • C. Deny the request until the sponsor approves.
  • D. Consult with the IRB/IEC first.
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Correct Answer: B  🗳️

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Question #4

A subject became pregnant 16 weeks into a clinical trial. She has been taking a daily dose of IP since enrollment. The baby was born missing two toes on each foot. How should this be reported by the site?

  • A. This qualifies for prompt reporting to the IRB/IEC within 15 business days.
  • B. This needs to be reported to the regulatory authorities within 10 business days.
  • C. This qualifies for expedited reporting to the sponsor.
  • D. This needs to be reported to the patient's primary care physician.
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Correct Answer: C  🗳️

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Question #5

Who is responsible for the ongoing safety evaluation of the IP?

  • A. IRB/IEC
  • B. Regulatory agency
  • C. Sponsor
  • D. PI
Reveal Solution  Discussion  0

Correct Answer: C  🗳️

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